Fujita Lab
Staff
Naonobu Fujita
(Associate Professor)
The molecular mechanisms shaping organelles in muscle cells
Differentiated muscle cells have highly organized organelles, such as Transverse (T)-tubules and sarcoplasmic reticulum for the synchronized contraction of the muscle. Their structures and functions are established; however, the mechanisms shaping the organelles are mostly unknown. Our study aims to elucidate the molecular mechanisms to form and remodel the membranous organelles in muscle cells using Drosophila and mammalian cultured cells. Further, we are trying to identify and characterize causative genes for hereditary human myopathies using by a combination of fly genetics and whole exome sequencing in patients.
Selected publications
- Fujita N, Huang W, Lin TH, Groulx JF, Jean S, Nguyen J, Kuchitsu Y, Koyama-Honda I, Mizushima N, Fukuda M, Kiger AA. Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy. Elife 2017, 6, e23367.
- Fujita N, Morita E, Itoh T, Tanaka A, Nakaoka M, Osada Y, Umemoto T, Saitoh T, Nakatogawa H, Kobayashi S, Haraguchi T, Guan JL, Iwai K, Tokunaga F, Saito K, Ishibashi K, Akira S, Fukuda M, Noda T, Yoshimori T. Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin. J. Cell Biol. 2013, 203, 115-128.
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