Kano Lab
Staff
Fumi Kano
(Associate Professor)
Daiki Nakatsu
(Assistant Professor)
[Masayuki Murata(Specially Appointed Professor)]
Cell-editing technology based on cell-resealing technique
Kano lab is devoted to the development of “Cell-editing technology” to control and design functions and fate of cells by using “cell-resealing technique”, which enables the free introduction of various molecules such as proteins, nucleotides, membrane-impermeable small molecules, etc. into cells (see figure). We also do research into integrating the analysis of cellular images obtained by microscopic observation with mathematical analysis to identify the key molecules for the various biological processes.
Current research directions of Kano lab include:
- Development of human iPS cell-editing system for cell therapy
- Frontier cellular image analysis to study biomolecular networks in disease cells
Selected publications
- Nakatsu D, Horiuchi Y, Kano F, Noguchi Y, Sugawara T, Takamoto I, Kubota N, Kadowaki T, Murata M. L-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2. Proc. Natl. Acad. Sci. USA. 2015, 112, E1067-1076.
- Taguchi Y, Imaoka K, Kataoka M, Uda A, Nakatsu D, Horii-Okazaki S, Kunishige R, Kano F, Murata M. Yip1A, a novel host factor for the activation of the IRE1 pathway of the unfolded protein response during Brucella infection. PLoS Pathogens 2015, journal.ppat.1004747.
- Kano F, Nakatsu D, Noguchi Y, Yamamoto A, Murata M. A resealed-cell system for analyzing pathogenic intracellular events: perturbation of endocytic pathways under diabetic conditions. PLoS ONE. 2012, 7, e44127.
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