Kano Lab
Staff
Fumi Kano
(Associate Professor)
Rina Kunishige
(Assistant Professor)
Masayuki Murata
(Specially Appointed Professor)
Cell-editing technology based on cell-resealing technique
Kano lab is devoted to the development of “Cell-editing technology” to control and design functions and fate of cells by using “cell-resealing technique”, which enables the free introduction of various molecules such as proteins, nucleotides, membrane-impermeable small molecules, etc. into cells (see figure). We also do research into integrating the analysis of cellular images obtained by microscopic observation with mathematical analysis to identify the key molecules for the various biological processes.
Current research directions of Kano lab include:
- Development of human iPS cell-editing system for cell therapy
- Frontier cellular image analysis to study biomolecular networks in disease cells
Selected publications
- Kunishige, R., Noguchi, Y., Okamoto, N., Li, L., Ono, A., Murata, M., Kano, F. Protein Covariation Networks for Elucidating Ferroptosis Inducer Mechanisms and Potential Synergistic Drug Targets Comms. Biol. 2025, 8, Article number: 480
- Nakatsu, D., Kunishige, R., Taguchi, Y., Shinozaki-Narikawa, N., Osaka, K., Yokomizo, K., Ishida, M., Takei, S., Yamasaki, S., Hagiya, K., Hattori, K., Tsukamoto, T., Murata, M., Kano, F. BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits neurogenesis and oligodendrogenesis in Alzheimer’s patients’ iPSCs in senescence-related conditions. Stem Cell Reports 2023, Volume 18, 688-705.
- Noguchi Y, Murakami M, Murata M, Kano F. Microscopic image-based classification of adipocyte differentiation by machine learning. Histochem. Cell Biol. 2022, Volume 159, Issue 4, 313–327.
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